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KMID : 0882420120820060744
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Korean Journal of Medicine
2012 Volume.82 No. 6 p.744 ~ p.748
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Immobilization-Induced Hypercalcemic Nephropathy Associated with Acute Kidney Injury
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Oh Hyun-Ju
Park Ji-Soo
Kim Jo-Eun
Yoon Ha-rry
Kim Ji-Soo
Kim Hyung-Jong
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Abstract
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Hypercalcemia commonly occurs because of primary hyperparathyroidism and metastatic malignancies, such as multiple myeloma, breast cancer and lung cancer; these causes account for 90% of cases. The other causes of hypercalcemia are numerous, and immobilization is an under-appreciated etiology. The mechanisms underlying immobilization-induced hypercalcemia are uncertain. However, an overall increased osteoclastic bone resorption and decreased osteoblastic bone formation can induce hypercalciuria and hypercalcemia. Additionally, hypercalcemia can induce and be associated with acute kidney injury, but it is rarely reported in immobilization hypercalcemia. We report here a 58-year-old man with suspected immobilization hypercalcemia associated with acute kidney injury and treated successfully with glucocorticoids.
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KEYWORD
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Hypercalcemia, Acute kidney injury, Immobilization, Glucocorticoids
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